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Several explanations for the encephalopathy in RS including false neurotransmitter activity have been postulated. Our group has recently demonstrated preliminary evidence of a disturbance in
tyrosine metabolism resulting in hypertyraminemia in 14 patients (Ped.64:76,1979). Additionally, we have observed hyperprolactinemia in three cases of stage IV RS (Lancet 2:1097,1979).
Utilizing the same radioimmunoassay techniques, plasma tyramines (TM) were measured on 16 additional RS patients. Plasma TM on admission were significantly elevated 6.65 ng/ml ± 1.86 (mean ±
S.E.M., range 0.1-36.2) p
