1515 SUSTAINED IMPROVEMENT IN GROWTH VELOCITY (GV) & BONE HISTOLOGY (BH) WITH 250HD3 (250) THERAPY (RX) IN CHRONIC RENAL FAILURE (CRF)


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Linear growth failure is a major complication of CRF unique to children and is related to renal osteodystrophy (ROD). 19 children, ages 2.8-16.4 yrs with CRF and BH of osteomalacia (OM),


osteitis fibrosa (OF) or both (OFM) were given 1-2 mcg/kg/d of 25D to evaluate effects on ROD & GV. GV was defined by standard deviation scores on Tanner growth charts, the preferred method


of expressing growth in pts with CRF. Group GV (mean±SEM) was -1.75±.45 in the pre-Rx year, increasing to +.2±.31 after the 1st Rx yr, and correlated with an increase in serum 25D of 42±8


ng/ml to 244±20 ng/ml (r=.37, p