1497 urinary beta-2-microglobulin (β2m) as an index of renal tublar maturation in human neonates


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ABSTRACT Tubular reabsorption of β2M was previously reported to increase with conceptional age (CA) and to reflect maturation of renal tubular function. To study this concept further,


timed-urine collections and blood samples were obtained on 50 newborn infants (CA 28-42 wks) between 1-12 days of age. Creatinine, sodium and β2M were measured in urine and plasma;


creatinine clearance (CCR) and fractional reabsorption of sodium (TNa) and β2M (Tβ2M) were calculated. Plasma β2M concentrations (3.63 ± 0.14 mg/liter, mean ± SE) did not vary with CA


(r=0.085). CCR (r=0.715), TNa (r=0.627) and Tβ2M (r=0.693) increased with CA of the infants (p<0.001). Moreover, Tβ2M varied directly with TNa (r=0.474, p<0.001) and inversely with


fractional urine flow rate (V/CCR) (r= -0.601, p<0.001). In serial studies of 18 infants 3.64 ± 0.67 (range 1-12) days later, changes in Tβ2M in the same infant were observed to vary


inversely with changes in V/CCR (r= -0.470, p=0.05). Although the results of this study confirm previous reports that Tβ2M increases with CA of the infant, these data do not support Tβ2M as


a reliable index of renal tubular maturation in the human neonate. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, University of Texas Southwestern


Medical School, Dallas William D Engle & Billy S Arant Jr. Authors * William D Engle View author publications You can also search for this author inPubMed Google Scholar * Billy S Arant


Jr. View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Engle, W.,


Arant, B. 1497 URINARY BETA-2-MICROGLOBULIN (β2M) AS AN INDEX OF RENAL TUBLAR MATURATION IN HUMAN NEONATES. _Pediatr Res_ 15 (Suppl 4), 692–693 (1981).


https://doi.org/10.1203/00006450-198104001-01526 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01526 SHARE THIS ARTICLE Anyone you share the


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