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Tubular reabsorption of β2M was previously reported to increase with conceptional age (CA) and to reflect maturation of renal tubular function. To study this concept further, timed-urine
collections and blood samples were obtained on 50 newborn infants (CA 28-42 wks) between 1-12 days of age. Creatinine, sodium and β2M were measured in urine and plasma; creatinine clearance
(CCR) and fractional reabsorption of sodium (TNa) and β2M (Tβ2M) were calculated. Plasma β2M concentrations (3.63 ± 0.14 mg/liter, mean ± SE) did not vary with CA (r=0.085). CCR (r=0.715),
TNa (r=0.627) and Tβ2M (r=0.693) increased with CA of the infants (p
