861 pneumococcal immunization of patients with sickle cell disease (scd): reactions and antibody (ab) response


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ABSTRACT Patients with SCD (n=174) immunized with PV had a high rate (70%) of mild reactions, primarily at the site of injection and directly associated (p <0.01) with the level of


preimmunization pneumococcal IHA Ab titer. Ab response to different antigens followed 3 patterns: poor or good response regardless of age at immunization and improving response with


advancing age at immunization; increase in Ab was strongly correlated (p <0.0005) with increasing level of preimmunization Ab. In 24 months of surveillance 3 episodes of type 23


pneumococcal sepsis were documented in study patients: 2 children under age 30 months (incidence, 4.40/100 patient years in children age 1-4 years) and a child age 5.6 years (0.66/100


patient years in children ≥5 years). The incidence of pneumococcal sepsis among nonimmunized children age 1-4 years followed at Los Angeles County-University of Southern California SCD


Center was 6.20-9.03/100 patient years. Therefore, anamnestic response seems to contribute strongly to the enhanced Ab response observed in older children. Only modest vaccine protection may


be expected among children with SCD who receive a single dose of PV. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * SCD PneumococcaTvaccine (PV) Collaborative Study Group. Univ.


of So. Calif. Sch. of Med., LACUSC Med. Ctr., Dept. of Ped., Los Angeles, Ca. Jose G Rigau Perez, Gary D Overturf & Darleen Powars Authors * Jose G Rigau Perez View author publications


You can also search for this author inPubMed Google Scholar * Gary D Overturf View author publications You can also search for this author inPubMed Google Scholar * Darleen Powars View


author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Rigau Perez, J.,


Overturf, G. & Powars, D. 861 PNEUMOCOCCAL IMMUNIZATION OF PATIENTS WITH SICKLE CELL DISEASE (SCD): REACTIONS AND ANTIBODY (Ab) RESPONSE. _Pediatr Res_ 15 (Suppl 4), 586 (1981).


https://doi.org/10.1203/00006450-198104001-00886 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00886 SHARE THIS ARTICLE Anyone you share the


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