Glucose disposal in the well low birth weight (lbw) infant


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ABSTRACT Glucose is the primary substrate for energy during parenteral alimentation of LBW infants. Hyperglycemia may result in glucosuria and osmotic diuresis when excessive glucose is


infused. Tolerance for glucose was studied in 35 appropriate for gestational age well LBW infants (birth wt. M = 1216 gms, gestational age M = 30 wks) between 3-38 days of age. Infants


received glucose: 8,11, or 14 mg/Kg/min for 3 hours by continuous peripheral intravenous infusion. Plasma glucose and insulin, and timed urine glucose and volume were measured (MtS.E.M.). A


steady state (S-S) of plasma glucose was noted by one hour at all infusion rates. There were significant increases in S-S plasma glucose (p<.001) and insulin (p<0.05) in Groups B and C


compared to Group A. Glycosuria did not exceed 0.28 mg/Kg/min, so that glucose disposal (retention) exceeded 97.7% of infusate. Group B was heterogeneous with respect to plasma glucose and


plasma insulin responses. No significant osmotic diuresis from glucose was noted. The data suggests well LBW infants tolerate glucose to 14 mg/Kg/min between 3-38 days of age without


significant glucosuria. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pediatrics, Brown University Program in Medicine, Women and Infants Hospital of R. I. and


Rhode Island Hospital, Providence, R.L. Richard M Cowett, Arnold Pollak, Barbara S Ross, Robert Schwartz & William Oh Authors * Richard M Cowett View author publications You can also


search for this author inPubMed Google Scholar * Arnold Pollak View author publications You can also search for this author inPubMed Google Scholar * Barbara S Ross View author publications


You can also search for this author inPubMed Google Scholar * Robert Schwartz View author publications You can also search for this author inPubMed Google Scholar * William Oh View author


publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Cowett, R., Pollak, A., Ross, B.


_et al._ GLUCOSE DISPOSAL IN THE WELL LOW BIRTH WEIGHT (LBW) INFANT. _Pediatr Res_ 11, 512 (1977). https://doi.org/10.1203/00006450-197704000-00855 Download citation * Issue Date: 01 April


1977 * DOI: https://doi.org/10.1203/00006450-197704000-00855 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a


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