Two molecular species of protoporphyrin in lead intoxication and iron deficiency anemia;


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ABSTRACT In iron deficiency anemia (FeDA) and lead intoxication (Pbl) the final step in heme synthesis is deranged in such a manner that protoporphyrin (PP) accumulates within the red blood


cells. A Zinc-PP chelate (ZnPP) is the primary species of PP present in these conditions. By fluorescent spectra we have found some free (unchelated) PP in addition to ZnPP in the rbcs of


children with FeDA and Pbl. In fact, in one child with acute FeDA the predominant species present was free PP, and this PP was changed to ZnPP during the course of treatment. Sequential


studies of lead-poisoned rats show that PP in the peripheral blood increases rapidly (within a week of exposure) and that initially free PP is the predominant species; as exposure continues


ZnPP becomes more prominent. Density gradient separation of these rbcs reveals that the youngest cells contain a large amount of PP, which is mainly free, while the older cells contain


predominantly ZnPP. Therefore, in the rat the proportion of ZnPP to free PP increases in the rbc, both with chronic lead exposure and with increasing cell age. These data indicate that in


Pbl and FeDA the PP produced in the rbcs is initially tree PP which subsequently chelates zinc. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pediatrics, NYU


Medical Center and NY Hospital-Cornell Medical Center, New York, N. Y. David A Hart, Seraio Plomelli & Joseph H Graziano Authors * David A Hart View author publications You can also


search for this author inPubMed Google Scholar * Seraio Plomelli View author publications You can also search for this author inPubMed Google Scholar * Joseph H Graziano View author


publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hart, D., Plomelli, S. &


Graziano, J. TWO MOLECULAR SPECIES OF PROTOPORPHYRIN IN LEAD INTOXICATION AND IRON DEFICIENCY ANEMIA;. _Pediatr Res_ 11, 472 (1977). https://doi.org/10.1203/00006450-197704000-00614 Download


citation * Issue Date: 01 April 1977 * DOI: https://doi.org/10.1203/00006450-197704000-00614 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:


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