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ABSTRACT Using a new procedure that combines electron-density correlation with biochemical information, we have fitted the crystal structure of the N-terminal actin-binding domain of human
T-fimbrin to helical reconstructions of fimbrin-decorated actin filaments. The map locates the N-terminal calcium-binding domain and identifies actin-binding site residues on the two
calponin-homology domains of fimbrin. Based on this map, we propose a model of a fimbrin crosslink in an actin bundle and its regulation by calcium. Access through your institution Buy or
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AND DISASSEMBLY Article Open access 11 September 2024 A STRUCTURAL MODEL OF THE PROFILIN–FORMIN PACEMAKER SYSTEM FOR ACTIN FILAMENT ELONGATION Article Open access 28 November 2022 REFERENCES
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Download references ACKNOWLEDGEMENTS D.H. and N.V. wish to thank A. Brilliant for his valuable contributions to the graphics displayed in this paper. This work was supported by National
Institutes of Health grants to D.DeR., W. L., R. C. (F. S. Fay), S.A. and P.M. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * The W.M. Keck Institute for Cellular Visualization, Brandeis
University, Waltham, 02254, Massachusetts, USA Dorit Hanein & David DeRosier * Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, 02254, Massachusetts, USA
Niels Volkmann * Department of Biochemistry, Albert Einstein College of Medicine, Bronx, 10461, New York, USA Sharon Goldsmith & Steve Almo * Department of Physiology, Boston University
School of Medicine, Boston, 02118, Massachusetts, USA William Lehman * Department of Cell Biology, University of Massachusetts Medical School, Worcester, 01655, Massachusetts, USA Roger
Craig * Department of Biology, Whitehead Institute for Biomedical Research, MIT, Cambridge, 02142, Massachusetts, USA Anne-Marie Michon & Paul Matsudaira Authors * Dorit Hanein View
author publications You can also search for this author inPubMed Google Scholar * Niels Volkmann View author publications You can also search for this author inPubMed Google Scholar * Sharon
Goldsmith View author publications You can also search for this author inPubMed Google Scholar * Anne-Marie Michon View author publications You can also search for this author inPubMed
Google Scholar * William Lehman View author publications You can also search for this author inPubMed Google Scholar * Roger Craig View author publications You can also search for this
author inPubMed Google Scholar * David DeRosier View author publications You can also search for this author inPubMed Google Scholar * Steve Almo View author publications You can also search
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permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hanein, D., Volkmann, N., Goldsmith, S. _et al._ An atomic model of fimbrin binding to F-actin and its implications for filament crosslinking
and regulation. _Nat Struct Mol Biol_ 5, 787–792 (1998). https://doi.org/10.1038/1828 Download citation * Received: 18 June 1998 * Accepted: 05 August 1998 * Issue Date: September 1998 *
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