AR-Vs not predictive in mCRPC | Nature Reviews Urology


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Access through your institution Buy or subscribe A new report in _European Urology_ shows that expression of androgen receptor variants 7 and 9 (AR-V7 and AR-V9) measured in whole blood is


not predictive of treatment outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC). “AR-Vs are truncated isoforms of the AR that retain constitutive activity and


are purported to be associated with resistance to novel hormonal therapies (abiraterone and enzalutamide),” explains Arun Azad, senior author of the study. “However, data from the ARMOR-3


trial called this belief into question; hence, we felt it was critical to assess AR-V7 and AR-V9 expression in patients with mCRPC to determine the predictive utility of these AR variants.”


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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * To, S. Q. _ et al_. Expression of androgen receptor splice variant


7 or 9 in whole blood does not predict response to androgen-axis–targeting agents in metastatic castration-resistant prostate cancer. _Eur. Urol._


https://doi.org/10.1016/j.eururo.2018.01.007 (2018) Article  CAS  Google Scholar  * Attard, G. & Antonarakis, E. S. Prostate cancer: AR aberrations and resistance to abiraterone or


enzalutamide. _Nat. Rev. Urol._ 13, 697–698 (2016) Article  CAS  Google Scholar  Download references Authors * Clemens Thoma View author publications You can also search for this author


inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Thoma, C. AR-Vs not predictive in mCRPC. _Nat Rev Urol_ 15, 203 (2018).


https://doi.org/10.1038/nrurol.2018.24 Download citation * Published: 27 February 2018 * Issue Date: April 2018 * DOI: https://doi.org/10.1038/nrurol.2018.24 SHARE THIS ARTICLE Anyone you


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