A step to identifying men at high risk of metastatic disease

Access through your institution Buy or subscribe New research shows that 11.8% of patients with metastatic prostate cancer carry germline DNA mutations in genes encoding proteins involved in

DNA repair, in contrast to only 4.6% of men with localized disease. Many men diagnosed with prostate cancer do not develop aggressive disease and might not require definitive treatment.

Identifying those patients whose tumour has the potential to metastasize is critical to provide the best possible treatment and improve patient outcomes. However, a tool to effectively

identify men with prostate cancer who have a high risk of developing metastatic disease is lacking. This is a preview of subscription content, access via your institution ACCESS OPTIONS

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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Pritchard, C. C. _ et al_. Inherited DNA-repair gene mutations in men with metastatic prostate cancer. _N.

Engl. J. Med._ http://dx.doi.org/10.1056/NEJMoa1603144 (2016) Download references Authors * Clemens Thoma View author publications You can also search for this author inPubMed Google

Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Thoma, C. A step to identifying men at high risk of metastatic disease. _Nat Rev Urol_ 13, 493

(2016). https://doi.org/10.1038/nrurol.2016.140 Download citation * Published: 26 July 2016 * Issue Date: September 2016 * DOI: https://doi.org/10.1038/nrurol.2016.140 SHARE THIS ARTICLE

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