Transdifferentiate to prevail | Nature Reviews Urology


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Access through your institution Buy or subscribe New _in vitro_ and _in silico_ data published in _Cancer Research_ demonstrate that long-term androgen deprivation causes human prostate


cancer cells to transdifferentiate into nonmalignant neuroendocrine-like (NEL) cells that sustain the growth of castration-resistant tumour cells. Neuroendocrine differentiation is known to


assist in the development of prostate adenocarcinomas and has been correlated to poor prognosis, but the exact mechanism of this process has not been fully elucidated. “We designed our study


to investigate a possibly more human-like model of androgen resistance than permitted by classical protocols of neuroendocrine differentiation,” explains corresponding author Alessia


Ligresti, Institute of Biomolecular Chemistry, Pozzuoli, Italy. “We adopted a multilevel approach based on different 'omic' sciences and mathematical modelling to overcome the


limitations of previous experiments.” This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive


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REFERENCES * Cerasuolo, M. _ et al_. Neuroendocrine transdifferentiation in human prostate cancer cells: an integrated approach. _Cancer Res._ 10.1158/0008-5472.CAN-14-3830 Download


references Authors * Clemens Thoma View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE


CITE THIS ARTICLE Thoma, C. Transdifferentiate to prevail. _Nat Rev Urol_ 12, 416 (2015). https://doi.org/10.1038/nrurol.2015.156 Download citation * Published: 30 June 2015 * Issue Date:


August 2015 * DOI: https://doi.org/10.1038/nrurol.2015.156 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a


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