Intravesical 'shock absorber' provides relief from sui

Access through your institution Buy or subscribe Inspired by industrial hydraulic systems, the research team came up with the concept of a gas-filled balloon that sits in the bladder and

absorbs spikes of pressure that are transmitted from the abdomen during physical activity. Their prototype is made of biocompatible medical grade polyurethane and is inserted via the urethra

without anaesthesia or analgesia. Once placed in the bladder, the balloon is inflated with 15 cm3 of air and 0.5 cm3 of a perfluorocarbon liquid that prevents diffusion of air through the

polyurethane. A one-way valve seals the balloon after inflation. The device has a low mass (0.2 g) and inherent buoyancy, enabling it to float at the dome of the bladder rather than

occluding the bladder outlet during voiding. 166 women with SUI symptoms (demonstrated on urodynamics or by cough test) were recruited at 13 sites across the USA and randomized to receive

either the pressure-attenuation device (_n_ = 112) or sham procedure (_n_ = 54). The device was changed (or sham procedure repeated) every 90 days. After 6 months, women who received the

device had significantly improved symptoms compared with those in the control arm, based on the number of women who reached a composite end point of ≥50% reduction in provocative pad weight

test and a subjective measure of improvement in urine leakage (50.8% versus 16.3%; _P_ <0.001). This improvement was also evident when the data were analysed on an intent-to-treat basis

(32% versus 15%; _P_ <0.001). This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12

print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be

subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL

RESEARCH PAPER * Rovner, E. S. _ et al_. A randomized, controlled clinical trial of a novel intravesical pressure-attenuation device for the treatment of stress urinary incontinence. _J.

Urol._ doi:10.1016/j.juro.2013.06.042 Download references Authors * Sarah Payton View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Payton, S. Intravesical 'shock absorber' provides relief from SUI. _Nat Rev Urol_ 10, 432 (2013).

https://doi.org/10.1038/nrurol.2013.150 Download citation * Published: 09 July 2013 * Issue Date: August 2013 * DOI: https://doi.org/10.1038/nrurol.2013.150 SHARE THIS ARTICLE Anyone you

share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the

Springer Nature SharedIt content-sharing initiative