In brief | Nature Reviews Urology


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Access through your institution Buy or subscribe Elucidating the role of the androgen receptor in castrate-resistant prostate cancer should facilitate discovery of therapeutic targets. An


international collaborative effort has revealed that the androgen receptor directly and selectively upregulates certain M-phase cell cycle genes, thereby promoting progression of


androgen-independent forms of the disease. _UBE2C_, which inactivates the M-phase checkpoint, was one of the key genes found to be upregulated. Wang, Q. _ et al_. Androgen receptor regulates


a distinct transcription program in androgen-independent prostate cancer. _Cell_ 138, 245–256 (2009). This is a preview of subscription content, access via your institution ACCESS OPTIONS


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institutional subscriptions * Read our FAQs * Contact customer support RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE In brief . _Nat Rev Urol_ 6, 464


(2009). https://doi.org/10.1038/nrurol.2009.164 Download citation * Issue Date: September 2009 * DOI: https://doi.org/10.1038/nrurol.2009.164 SHARE THIS ARTICLE Anyone you share the


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