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Access through your institution Buy or subscribe In the search for structure-modifying treatments for osteoarthritis (OA), could the answer lie not in preventing degradation of cartilage,
but in stimulating its growth and regeneration? A proof-of-concept study led by L. Stefan Lohmander at Lund University, Sweden, shows that intra-articular injection of a synthetic form of
human fibroblast growth factor 18 (FGF18), known as sprifermin, could reduce the cartilage loss characteristic of knee OA. Sprifermin, which signals through FGFR3 receptors in cartilage, had
previously been shown in preclinical studies to promote chondrogenesis, cartilage matrix formation and cartilage repair _in vitro_, and to slow or protect joint cartilage from destruction
in animal models of OA. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print
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local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES *
Lohmander, S. _ et al_. Intra-articular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: randomized, double-blind, placebo-controlled trial. _Arthritis
Rheum._ 10.1002/art.38614 Download references Authors * Sarah Onuora View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and
permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Onuora, S. Sprifermin shows cartilage-protective effects in knee OA. _Nat Rev Rheumatol_ 10, 322 (2014).
https://doi.org/10.1038/nrrheum.2014.68 Download citation * Published: 06 May 2014 * Issue Date: June 2014 * DOI: https://doi.org/10.1038/nrrheum.2014.68 SHARE THIS ARTICLE Anyone you share
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