Understanding hypercitrullination in rheumatoid arthritis


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Access through your institution Buy or subscribe The generation of citrullinated antigens in rheumatoid arthritis (RA), as a result of so-called cellular hypercitrullination, is induced by


immune-mediated pore-forming pathways, according to new research published in _Science Translational Medicine_. The findings add insights into the role of immune-mediated membranolytic


pathways in the development of RA, offering hope for new opportunities for early monitoring and treatment of this disease. > Abnormal protein citrullination is suspected of sparking the 


immune > system and driving ... the development of RA This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to


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support REFERENCES * Romero, V. _ et al_. Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis. _Sci.


Transl. Med._ 5, 209ra150 (2013) Article  Google Scholar  Download references Authors * Katrina Ray View author publications You can also search for this author inPubMed Google Scholar


RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ray, K. Understanding hypercitrullination in rheumatoid arthritis. _Nat Rev Rheumatol_ 10, 3 (2014).


https://doi.org/10.1038/nrrheum.2013.182 Download citation * Published: 19 November 2013 * Issue Date: January 2014 * DOI: https://doi.org/10.1038/nrrheum.2013.182 SHARE THIS ARTICLE Anyone


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