Immune responses in mikulicz disease differ from those in ss

Access through your institution Buy or subscribe In MD, a T-helper (TH) 2 and T-regulatory (TREG) response predominates with selective infiltration of IgG4+ plasma cells and TREG cells into

affected salivary glands. By contrast, various types of lymphocytes were observed in patients with SS with an accompanying TH1, TH2 and TH17 immune response. “These findings suggest that MD

is a unique inflammatory disorder,” says senior author Seiji Nakamura. MD is characterized by swollen salivary and lacrimal glands as a result of lymphocyte infiltration. A key feature of

MD, according to Nakamura, is elevated levels of IgG4 antibodies. As evidence has indicated that IL-4 and IL-10 induce IgG4 production, Nakamura _ et al_. investigated the immune reactions

in patients with MD or SS to elucidate the pathogenesis of these diseases. The researchers obtained biopsy samples from salivary glands of patients with MD (_n_ = 15) or SS (_n_ = 18), and

compared them with samples from healthy controls (_n_ = 18). Using immunohistochemical and real-time PCR analysis, the study authors revealed the different subsets of infiltrating cells and

mRNA expression patterns of cytokines, chemokines and chemokine receptors in the samples. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through

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Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Tanaka, A. _ et al_. Th2 and regulatory immune reactions contributes to IgG4 production and the initiation of

Mikulicz's disease. _Arthritis Rheum._ doi:10.1002/art.33320 Download references Authors * Katrina Ray View author publications You can also search for this author inPubMed Google

Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ray, K. Immune responses in Mikulicz disease differ from those in SS. _Nat Rev Rheumatol_ 7, 621

(2011). https://doi.org/10.1038/nrrheum.2011.146 Download citation * Published: 04 October 2011 * Issue Date: November 2011 * DOI: https://doi.org/10.1038/nrrheum.2011.146 SHARE THIS ARTICLE

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