Laminins control t-cell entry into the cns

Access through your institution Buy or subscribe Wu, C. _ et al_. Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain. _Nat. Med._ 15,

519–527 (2009). A key experimental observation was made in the laminin α4 knockout mouse, which also shows ubiquitous laminin α5 expression in all endothelial cell basement membranes but

otherwise expresses normal adhesion molecules and junctional proteins. “In a model where the endothelial basement membrane contains no laminin α4, T lymphocytes show significantly reduced

migration into the CNS, suggesting that the laminins impart specific information to the T cell which controls migration,” notes Sorokin. Macrophage and dendritic cell infiltration of the CNS

was relatively unaffected. “This provides a rationale for specifically targeting T-lymphocyte infiltration into the CNS, particularly in autoimmune conditions such as MS,” she adds. This is

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the CNS. _Nat Rev Neurol_ 5, 351 (2009). https://doi.org/10.1038/nrneurol.2009.76 Download citation * Issue Date: July 2009 * DOI: https://doi.org/10.1038/nrneurol.2009.76 SHARE THIS ARTICLE

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