The hippocampus encodes objects in time

Access through your institution Buy or subscribe The hippocampus has an essential role in episodic memory, but its encoding mechanisms remain unclear. Two studies used pattern similarity

analysis of functional MRI data from tasks involving learning objects in temporal orders. Hsieh _et al_. found that hippocampal activity patterns contained information about objects and

their sequence positions rather than object or sequence information alone. In addition, they found that activity patterns in the right perirhinal cortex and the parahippocampal cortex were

associated with object and sequence position information, respectively. In a different study, Ezzyat and Davachi found that pattern similarity in the left hippocampus was higher when

subjects recalled temporally close objects that were presented in different 'scenes'. By contrast, the lateral occipital cortex exhibited higher pattern similarity when recalling

objects presented temporally close together in the same 'scene'. Overall, these studies demonstrate that the hippocampus may represent items in specific temporal positions, whereas

other nearby brain regions have different roles in encoding objects or temporal information. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

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Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional

subscriptions * Read our FAQs * Contact customer support REFERENCES * Hsieh, L.-T. et al. Hippocampal activity patterns carry information about objects in temporal context. _Neuron_ 81,

1165–1178 (2014) Article  CAS  Google Scholar  * Ezzyat, Y. & Davachi, L. Similarity breeds proximity: pattern similarity within and across contexts is related to later mnemonic

judgments of temporal proximity. _Neuron_ 81, 1179–1189 (2014) Article  CAS  Google Scholar  Download references Authors * Natasha Bray View author publications You can also search for this

author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bray, N. The hippocampus encodes objects in time. _Nat Rev Neurosci_ 15,

281 (2014). https://doi.org/10.1038/nrn3735 Download citation * Published: 09 April 2014 * Issue Date: May 2014 * DOI: https://doi.org/10.1038/nrn3735 SHARE THIS ARTICLE Anyone you share the

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