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Access through your institution Buy or subscribe > mice that lack long 3′ UTR _Bdnf_ mRNA exhibit increased food > intake ... and develop severe obesity The _Bdnf_ gene produces
transcripts with either a long or short 3′ untranslated region (UTR), and previous studies have shown that long 3′ UTR _Bdnf_ mRNA is transported from the nucleus to neuronal dendrites,
where it is locally translated. In this study, the authors found that transgenic mice that lack long 3′ UTR _Bdnf_ mRNA exhibit increased food intake — consuming 69–80% more food than their
wild-type counterparts — and develop severe obesity. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this
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Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer
support ORIGINAL RESEARCH PAPER * Liao, G.-Y. et al. Dendritically targeted _Bdnf_ mRNA is essential for energy balance and response to leptin. _Nature Med._ 18 Mar 2012
(doi:10.1038/nm.2687) Article CAS PubMed PubMed Central Google Scholar Download references Authors * Katherine Whalley View author publications You can also search for this author
inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Whalley, K. Controlling consumption. _Nat Rev Neurosci_ 13, 288–289 (2012).
https://doi.org/10.1038/nrn3233 Download citation * Published: 04 April 2012 * Issue Date: May 2012 * DOI: https://doi.org/10.1038/nrn3233 SHARE THIS ARTICLE Anyone you share the following
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