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Access through your institution Buy or subscribe COMMUNICATION VIA GAP JUNCTIONS UNDERLIES EARLY FUNCTIONAL AND BENEFICIAL INTERACTIONS BETWEEN GRAFTED NEURAL STEM CELLS AND THE HOST


Jäderstad, J. _et al_. _Proc. Natl Acad. Sci. USA_ 10 February 2010 (doi: 10.1073/pnas.0915134107) How do grafted neural stem cells (NSCs) interact with existing neurons? NSCs transplanted


into the cerebellum of mouse models of Purkinje cell death formed functional connexin 43-containing gap junctions with existing neurons. The grafts influenced host network activity,


increased host neuron survival and rescued behavioural deficits. These effects could be inhibited by blocking gap junction formation or function, suggesting that NSC–neuron communication


through gap junctions has modulatory and protective actions. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe


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