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Access through your institution Buy or subscribe The authors screened for _Drosophila melanogaster_ dendritic arbor reduction (dar) mutants and identified — among others — _dar3_, a gene
that has been implicated in ER-to-Golgi trafficking. Interestingly, mutations in the mammalian _dar3_ homologue, _SAR1_ , also reduced dendritic length in cultured hippocampal neurons,
pointing to an evolutionarily conserved role for this protein. Furthermore, the rate of membrane supply to dendrites, but not to axons, was impaired in _SAR1_ mutants, suggesting that
dendritic and axonal growth rely on different membrane supply mechanisms. Jan and colleagues noticed that mutations in _dar3_ and _SAR1_ not only reduced the overall dendritic length in _D.
melanogaster_ neurons and cultured hippocampal neurons, respectively, but also changed the appearance of the normally compact Golgi structures in the soma and dendrites (Golgi outposts) such
that they were more diffuse, suggesting that dar3 and SAR1 are required for normal Golgi morphology. This is a preview of subscription content, access via your institution ACCESS OPTIONS
Access through your institution Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Learn more Buy this article * Purchase on
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institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Ye, B. et al. Growing dendrites and axons differ in their reliance on the secretory pathway.
_Cell_ 130, 717–729 (2007) Article CAS Google Scholar Download references Authors * Claudia Wiedemann View author publications You can also search for this author inPubMed Google Scholar
RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wiedemann, C. Bricks for different houses. _Nat Rev Neurosci_ 8, 737 (2007).
https://doi.org/10.1038/nrn2247 Download citation * Issue Date: October 2007 * DOI: https://doi.org/10.1038/nrn2247 SHARE THIS ARTICLE Anyone you share the following link with will be able
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