Regulating olfactory receptors

Access through your institution Buy or subscribe Two new studies provide evidence that the monoallelic expression pattern of olfactory receptors (ORs) in mammals is regulated by a negative

feedback mechanism. Sakano and colleagues used transgenic constructs in yeast artificial chromosomes to manipulate expression of the _MOR28_ gene in mice. Transformation of mice with

enhanced green fluorescent protein (EGFP)-tagged _MOR28_ from which the entire coding sequence had been deleted resulted in co-expression of EGFP and endogenous _MOR28_ in many cells. Other

EGFP-positive neurons of the olfactory epithelium expressed different endogenous OR genes, indicating that a product of the _MOR28_ coding sequence is required to prevent the expression of

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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL RESEARCH PAPERS *

Serizawa, S. et al. Negative feedback regulation ensures the one receptor–one olfactory neuron rule in mouse. _Science_ 302, 2088–2094 (2003) Article  CAS  Google Scholar  * Lewcock, J. W.

& Reed, R. R. A feedback mechanism regulates monoallelic odorant receptor expression. _Proc. Natl Acad. Sci. USA_ 101, 1069–1074 (2004) Article  CAS  Google Scholar  FURTHER READING *

Laurent, G. Olfactory network dynamics and the coding of multidimensional signals. _Nature Rev. Neurosci._ 3, 884–895 (2002) Article  CAS  Google Scholar  Download references Authors *

Suzanne Farley View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Farley, S. Regulating olfactory receptors. _Nat Rev Neurosci_ 5, 171 (2004). https://doi.org/10.1038/nrn1361 Download citation * Issue Date: 01 March 2004 * DOI:

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