Prokaryotic argonaute proteins: novel genome-editing tools?

ABSTRACT Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but

homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved

in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing. Access through your institution Buy or subscribe This is a preview

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GUIDE AND TARGET STRANDS BY THE _ARCHAEOGLOBUS FULGIDUS_ ARGONAUTE PROTEIN Article Open access 14 April 2023 DNA TARGETING AND INTERFERENCE BY A BACTERIAL ARGONAUTE NUCLEASE Article 30 July

2020 DNA-TARGETING SHORT ARGONAUTES COMPLEX WITH EFFECTOR PROTEINS FOR COLLATERAL NUCLEASE ACTIVITY AND BACTERIAL POPULATION IMMUNITY Article 15 April 2024 ACCESSION CODES ACCESSIONS PROTEIN

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authors' laboratory was financially supported by a grant from the Netherlands Organization of Scientific Research (NWO-ECHO grant 711013002 and NWO-TOP grant 714015001) to J.v.d.O., and

by a long-term postdoctoral fellowship from the European Molecular Biology Organization (EMBO) to D.C.S. (ALTF 179–2015). AUTHOR INFORMATION Author notes * Jorrit W. Hegge and Daan C.

Swarts: J.W.H and D.C.S contributed equally to this work. AUTHORS AND AFFILIATIONS * Department of Agrotechnology and Food Sciences, Laboratory of Microbiology, Wageningen University,

Stippeneng 4, Wageningen, 6708WE, The Netherlands Jorrit W. Hegge & John van der Oost * Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, Zurich, CH-8057,

Switzerland Daan C. Swarts Authors * Jorrit W. Hegge View author publications You can also search for this author inPubMed Google Scholar * Daan C. Swarts View author publications You can

also search for this author inPubMed Google Scholar * John van der Oost View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to John van der Oost. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RELATED LINKS DATABASES RCSB Protein Data Bank 4Z4C 3F73

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ARTICLE CITE THIS ARTICLE Hegge, J., Swarts, D. & van der Oost, J. Prokaryotic Argonaute proteins: novel genome-editing tools?. _Nat Rev Microbiol_ 16, 5–11 (2018).

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