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Access through your institution Buy or subscribe > cell-to-cell transfer of α-synuclein is highly efficient When donor mouse catecholaminergic neuron-like cells (known as CAD cells)
pre-loaded with α-synuclein fibrils were co-cultured with naive acceptor CAD cells, 100% of the acceptor cells contained fibrillar α-synuclein after 24 hours, with an average of 38
α-synuclein puncta per acceptor cell compared with 70 puncta per donor cell. Thus, cell-to-cell transfer of α-synuclein is highly efficient. In line with previous studies, transferred
α-synuclein fibrils were shown to recruit and aggregate soluble α-synuclein in acceptor cells. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access
through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink *
Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional
subscriptions * Read our FAQs * Contact customer support REFERENCES * Abounit, S. et al. Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes. _EMBO J._
http://dx.doi.org/10.15252/embj.201593411 (2016) Download references Authors * Kirsty Minton View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Minton, K. Intracellular tunnels spread disease. _Nat Rev Mol Cell Biol_ 17, 609 (2016).
https://doi.org/10.1038/nrm.2016.124 Download citation * Published: 01 September 2016 * Issue Date: October 2016 * DOI: https://doi.org/10.1038/nrm.2016.124 SHARE THIS ARTICLE Anyone you
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