CD4s work the doors | Nature Reviews Immunology

Access through your institution Buy or subscribe Lymph nodes that drain inflamed tissues serve an important role in initiating adaptive immune responses by 'trapping' circulating

naive T cells to promote their interaction with DCs. This leads to the swelling that is characteristic of a reactive lymph node. The authors found that in the initial days following herpes

simplex virus (HSV) infection, CD4+ T cell-deficient mice showed decreased expansion of the lymph nodes draining infected tissues and impaired CTL development. This reduction in lymph node

expansion could not be explained solely by the deficiency of CD4+ T cells, as the numbers of B cells and CD8+ T cells were also decreased in the lymph node. A decrease in lymph node

cellularity was seen in CD4+ T cell-deficient mice as early as 2 days post HSV infection, suggesting that this was not caused by the loss of DC 'licensing' or late-phase CD8+ T

cell expansion. Furthermore, although the magnitude of the HSV-specific CD8+ T cell response was decreased in infected CD4+ T cell-deficient mice, the overall quality of the early CD8+ T

cell response (as measured by the rate of cell division and the expression of CD69 and granzymes) was similar to that observed in control animals. This suggested that the decreased CD8+ T

cell number in the CD4+ T cell-deficient mice was due to a failure of the initial entry and trapping of naive lymphocytes early in HSV infection. This is a preview of subscription content,

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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Kumamoto, Y. et al. CD4+ T cells support cytotoxic T

lymphocyte priming by controlling lymph node input. _Proc. Natl Acad. Sci. USA_ 9 May 2011 (doi:10.1073/pnas.1100567108) Article  CAS  Google Scholar  Download references Authors * Yvonne

Bordon View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bordon, Y.

CD4s work the doors. _Nat Rev Immunol_ 11, 371 (2011). https://doi.org/10.1038/nri3001 Download citation * Published: 25 May 2011 * Issue Date: June 2011 * DOI:

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