TNF rises to the occasion | Nature Reviews Immunology

Access through your institution Buy or subscribe TNF-antagonist therapy is widely used to treat inflammatory and autoimmune diseases, such as rheumatoid arthritis, in which dysregulated or

excessive TNF production has been implicated. However, there is evidence to suggest that TNF-specific therapy is linked to an increased incidence of malignancies in patients with rheumatoid

arthritis. Understanding the consequences of TNF blockade, therefore, is important, but is complicated by contradictory reports on the role of TNF in the regulation of T-cell responses. To

address this issue, Calzascia _et al_. investigated whether the involvement and relevance of TNF in immunity is associated with the immunostimulatory properties of the antigen. They used the

lymphocytic choriomeningitis virus (LCMV) glycoprotein as a model antigen in LCMV infection (which induces a strong inflammatory response) or in a tumour model (in which a

glycoprotein-expressing spontaneous tumour acts as a stimulus associated with limited immunostimulatory capacity). This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Calzascia, T. et al. TNF-α is critical for antitumor but not antiviral T cell immunity

in mice. _J. Clin. Invest._ 8 November 2007 (doi:10.1172/JCI32567) Download references Authors * Sharon Ahmad View author publications You can also search for this author inPubMed Google

Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ahmad, S. TNF rises to the occasion. _Nat Rev Immunol_ 7, 920 (2007).

https://doi.org/10.1038/nri2223 Download citation * Issue Date: December 2007 * DOI: https://doi.org/10.1038/nri2223 SHARE THIS ARTICLE Anyone you share the following link with will be able

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