Oral capsule fmt effective for c. Difficile infection


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Access through your institution Buy or subscribe Although useful in preventing recurrent _Clostridium difficile_ infection (RCDI), whether the clinical effectiveness of faecal microbiota


transplantation (FMT) is altered by delivery route was previously unknown. In a multicentre, randomized controlled trial, 116 adults with RCDI randomly received FMT by either oral capsule or


colonoscopy. After 12 weeks, 92.6% of patients in both groups achieved prevention of RCDI after a single treatment. Minor adverse events were less frequent in the capsule group (5.4%) than


the colonoscopy group (12.5%), and a greater proportion of participants in the capsule group rated the procedure as “not at all unpleasant”. These findings demonstrate that FMT via oral


capsules is effective for treating RCDI and is not inferior to delivery by colonoscopy. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through


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support REFERENCES * Kao, D. _ et al_. Effect of oral capsule- vs colonoscopy-delivered fecal microbiota transplantation on recurrent _Clostridium difficile_ infection: a randomized clinical


trial. _JAMA_ 318, 1985–1993 (2017) Article  CAS  Google Scholar  Download references Authors * Iain Dickson View author publications You can also search for this author inPubMed Google


Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Dickson, I. Oral capsule FMT effective for _C. difficile_ infection. _Nat Rev Gastroenterol


Hepatol_ 15, 68 (2018). https://doi.org/10.1038/nrgastro.2017.188 Download citation * Published: 04 January 2018 * Issue Date: February 2018 * DOI: https://doi.org/10.1038/nrgastro.2017.188


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