Transcription factors tune in | Nature Reviews Genetics

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Access through your institution Buy or subscribe Hao and colleagues studied the yeast transcription factor Msn2, which generates distinct gene expression outcomes in response to different


stresses. In the absence of stress, Msn2 is phosphorylated by protein kinase A (PKA) and is located in the cytoplasm, but in response to stress it is dephosphorylated and translocated to the


nucleus. The dynamics of Msn2 translocation vary depending on the type of stress, and this variability is thought to result from different oscillating patterns of PKA activity. > 


signal-processing ability can result from the modular control of > transcription factor translocation This is a preview of subscription content, access via your institution RELEVANT


ARTICLES Open Access articles citing this article. * NEW INSIGHTS INTO FUNCTIONAL REGULATION IN MS-BASED DRUG PROFILING * Ana Sofia Carvalho * , Henrik Molina *  & Rune Matthiesen


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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Hao, N. et al. Tunable signal processing


through modular control of transcription factor translocation. _Science_ 339, 460–464 (2013) Article  CAS  PubMed  PubMed Central  Google Scholar  Download references Authors * Louisa


Flintoft View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Flintoft,


L. Transcription factors tune in. _Nat Rev Genet_ 14, 154–155 (2013). https://doi.org/10.1038/nrg3431 Download citation * Published: 05 February 2013 * Issue Date: March 2013 * DOI:


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