Orthologues undergo functional repurposing

Access through your institution Buy or subscribe This paper presents a genetic interaction map of _Schizosaccharomyces pombe_ and compares it with genetic interactions previously mapped in

_Saccharomyces cerevisiae_. The authors found widespread conservation of interactions, but a subset of orthologous complexes seems to have different functions. They term this evolution of

different partners or functional relationships 'repurposing' and link repurposing to important cellular processes, such as mitosis. This is a preview of subscription content,

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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Frost, A. et al. Functional repurposing revealed by comparing

_S. pombe_ and _S. cerevisiae_ genetic interactions. _Cell_ 149, 1339–1352 (2012) Article  CAS  Google Scholar  Download references Authors * Mary Muers View author publications You can

also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Muers, M. Orthologues undergo functional repurposing.

_Nat Rev Genet_ 13, 451 (2012). https://doi.org/10.1038/nrg3276 Download citation * Published: 18 June 2012 * Issue Date: July 2012 * DOI: https://doi.org/10.1038/nrg3276 SHARE THIS ARTICLE

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