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nucleosome patterns are context dependent and can be influenced by interplay among trans-acting factors, DNA sequence and genome function
Valouev and colleagues explored how sequence-driven nucleosome-positioning preferences relate to genome function in humans by generating genome-scale nucleosome maps in three primary cell
types and by assembling of histones onto genomic DNA in vitro. From an analysis of the positions occupied by nucleosomes in vitro and in vivo, these authors describe 'container sites' in the
DNA sequence that consist of a G/C core that attracts the nucleosome flanked by A/T sequences that repel the nucleosome. In vivo, they saw phased nucleosome positioning surrounding these
sites, which supports a model — known as 'statistical positioning' — in which nucleosomes can be positioned by packing against a barrier (in this case, a sequence-positioned nucleosome at
the container site).
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