Total interconnectedness of everything

Access through your institution Buy or subscribe Genes that have related functions often share expression patterns, and so microarray data can be used to investigate functional relationships

between genes. Stuart, Segal and colleagues constructed a gene co-expression network using pre-existing microarray data from four species; the assumption being that evolutionarily conserved

co-expression is an indicator of its functional significance. To make the network, the authors first associated genes from one organism with their orthologues from the others, using

all-against-all BLAST. Based on the highest BLAST scores, they identified 'meta-genes' that corresponded to sets of orthologues from the organisms used in the study. They came up

with 6,307 meta-genes that correspond to 6,591 human genes, 5,180 worm genes and so on. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through

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Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Stuart, J. M., Segal, E. et al. A gene coexpression network for global discovery of conserved genetic modules. _Science_ 21

August 2003 (10.1126/science.1087447) Download references Authors * Magdalena Skipper View author publications You can also search for this author inPubMed Google Scholar RELATED LINKS

RELATED LINKS WEB SITE Supplementary data RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Skipper, M. Total interconnectedness of everything. _Nat Rev

Genet_ 4, 760 (2003). https://doi.org/10.1038/nrg1188 Download citation * Issue Date: 01 October 2003 * DOI: https://doi.org/10.1038/nrg1188 SHARE THIS ARTICLE Anyone you share the following

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