Adenosine kinase inhibitor increases β-cells


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Increasing the number of insulin-producing β-cells could be beneficial in diabetes. Annes _et al_. showed that adenosine kinase inhibitors (AKIs) selectively promoted the replication of


primary β-cells (taken from mice, rats and pigs). They also showed that adenosine kinase acts as a cell-autonomous regulator of β-cell replication, and that AKI-mediated β-cell replication


involved activation of mammalian target of rapamycin. A single injection of the AKI ABT-702 into mice increased β-cell replication (but not exocrine cell or hepatocyte replication),


suggesting that AKIs might be useful in diabetes therapy. ORIGINAL RESEARCH PAPER * Annes, J. P. et al. Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell


replication. _Proc. Natl Acad. Sci. USA_ 15 Feb 2012 (doi:10.1073/pnas.1201149109) Article  CAS  Google Scholar  Download references RIGHTS AND PERMISSIONS Reprints and permissions ABOUT


THIS ARTICLE CITE THIS ARTICLE Adenosine kinase inhibitor increases β-cells. _Nat Rev Drug Discov_ 11, 274 (2012). https://doi.org/10.1038/nrd3710 Download citation * Published: 16 March


2012 * Issue Date: April 2012 * DOI: https://doi.org/10.1038/nrd3710 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry,


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