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Signal transducer and activator of transcription 3 (STAT3) exists in two main isoforms: STAT3α and STAT3β. STAT3β is generated by alternative splicing, and its overexpression can induce
apoptosis and inhibit tumour growth. This study used phosphorodiamidate morpholino oligomers to redirect STAT3 alternative splicing from STAT3α to STAT3β. This splicing switch was associated
with a reduced viability of cancer cells and tumour regression in a xenograft model, highlighting that redirection of alternative splicing could be a novel approach for cancer therapy.
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