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Hepatocellular carcinoma is a particularly lethal form of cancer, owing to typically late diagnosis and a lack of effective therapies. Now, writing in Cell, Kota and colleagues demonstrate
that reinstating the expression of a single microRNA (miRNA) that is specifically down regulated in liver cancer cells suppresses tumour progression, unveiling a new potential anticancer
strategy.
To explore their theory, they first set out to identify miRNAs that fitted this profile. miR-26a was found to be the most dramatically downregulated miRNA in cancer cells from a mouse liver
tumour model, as compared with normal liver cells. This finding was confirmed in human liver-derived hepatocellular carcinoma cells.
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