Angiotensin ii — a new tool in vasodilatory shock


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Access through your institution Buy or subscribe Patients with vasodilatory shock, characterized by peripheral vasodilatation and low arterial blood pressure, who do not respond to


vasopressors (catecholamines or vasopressin) have a poor prognosis. In addition, current vasopressors have toxic effects at high doses. A new clinical trial now shows that in patients with


catecholamine-resistant vasodilatory shock, intravenous administration of angiotensin II increases blood-pressure levels and allows dose reductions of concomitant vasopressors. The


researchers randomly assigned patients with vasodilatory shock receiving high-dose vasopressors to angiotensin II (_n_ = 163) or placebo (_n_ = 158) infusions. At 3 h, 69.9% patients in the


angiotensin II group met the primary end point (mean arterial blood pressure ≥75 mmHg or an increase of ≥10 mmHg from baseline) compared with 23.4% in the placebo group. Patients receiving


angiotensin II had lower catecholamine requirements and cardiovascular SOFA scores than those receiving placebo. Rates of serious adverse events, as well as 28-day mortality, were similar in


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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Khanna, A. _ et al_. Angiotensin II for the treatment


of vasodilatory shock. _N. Engl. J. Med._ http://dx.doi.org/10.1056/NEJMoa1704154 (2017) Download references Authors * Irene Fernández-Ruiz View author publications You can also search for


this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fernández-Ruiz, I. Angiotensin II — a new tool in vasodilatory shock.


_Nat Rev Cardiol_ 14, 384 (2017). https://doi.org/10.1038/nrcardio.2017.90 Download citation * Published: 14 June 2017 * Issue Date: July 2017 * DOI:


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