STAT3: friend or foe? | Nature Reviews Cancer


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Access through your institution Buy or subscribe Signal transducer and activator of transcription 3 (STAT3) has well-characterized oncogenic activities in various cancers. However,


Jacqueline Bromberg, David Lyden and colleagues found that, in clinical thyroid cancer samples, levels of phosphorylated (active) STAT3 negatively correlated with tumour size and metastasis.


Furthermore, loss of STAT3 expression increased thyroid cell tumorigenicity _in vivo_ in both xenograft and orthotopic mouse models. This study highlights a possible tumour suppressor role


for STAT3 in thyroid cancer, which may involve a STAT3-regulated metabolic switch. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your


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our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Couto, J. P. et al. STAT3 negatively regulates thyroid tumorigenesis. _Proc. Natl Acad. Sci. USA_ 109, E2361–E2370 (2012)


Article  CAS  Google Scholar  Download references Authors * Darren J. Burgess View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS


Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Burgess, D. STAT3: friend or foe?. _Nat Rev Cancer_ 12, 659 (2012). https://doi.org/10.1038/nrc3376 Download citation *


Published: 24 September 2012 * Issue Date: October 2012 * DOI: https://doi.org/10.1038/nrc3376 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:


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