p53 makes microRNAs mature | Nature Reviews Cancer

Access through your institution Buy or subscribe > ...the tumour suppressor protein p53 is an important regulator of > miRNA processing. The processing of primary (pri)-miRNA

transcripts into mature miRNAs involves the enzyme drosha (also known as ribonuclease 3), and in some cases drosha requires the RNA-associated proteins p68 and p72 for its function. The

authors noticed that p72-dependent miRNAs are upregulated under DNA-damaging conditions. As p53 protein levels are known to be upregulated in response to DNA damage, they tested the

involvement of p53 in miRNA processing. Exposure of cells to the DNA-damaging agent doxorubicin, a p53 inducer, increases the level of several mature miRNAs that have growth-suppressive

functions and are decreased in cancer. This accumulation occurs post-transcriptionally and is dependent on p53, p68 and p72. This is a preview of subscription content, access via your

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL RESEARCH PAPER * Suzuki, H. I. et al. Modulation of microRNA processing by p53.

_Nature_ 460, 529–533 (2009) Article  CAS  Google Scholar  FURTHER READING * Kim, V. N. et al. Biogenesis of small RNAs in animals. _Nature Rev. Mol. Cell Biol._ 10, 126–139 (2009) Article 

CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Associate Editor, Nature Reviews Molecular Cell Biology, Katharine H. Wrighton Authors * Katharine H.

Wrighton View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wrighton,

K. p53 makes microRNAs mature. _Nat Rev Cancer_ 9, 612–613 (2009). https://doi.org/10.1038/nrc2724 Download citation * Published: 13 August 2009 * Issue Date: September 2009 * DOI:

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