Expanding the pathway | Nature Reviews Cancer

Access through your institution Buy or subscribe The Sav–Wts–Hpo pathway limits organ size by restricting cell growth and proliferation, and by activating apoptosis. Using _D. melanogaster_

eye and wing discs as models for tissue growth, the groups showed that loss of the tumour suppressor Fat induces tissue overgrowth, unperturbed cell cycling and an inability to enter

senescence. This phenotype is the same as that generated by the loss of Sav–Wts–Hpo signalling in these tissues, in part owing to the deregulated expression of the Sav–Wts–Hpo target gene

cyclin E. Intriguingly, although the anti-apoptotic protein DIAP1 accumulates in _fat_ mutant tissue, _fat_ seems to be dispensable for developmental apoptosis. All three groups show that

Fat is genetically and biochemically upstream of, and a positive regulator of, members of the Sav–Wts–Hpo signalling pathway. Fat is a large transmembrane receptor, and the groups show that

Fat functions upstream of Expanded (Ex), one of the upstream components of the Sav–Wts–Hpo pathway Fat is required for the stability and/or localization of Ex to the apical membrane of

epithelial tissues. However, Fat was not required for the localization of Merlin, another upstream component, indicating that Merlin probably interacts with an alternative

membrane-associated protein in a parallel pathway to Fat–Ex. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe

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customer support ORIGINAL RESEARCH PAPERS * Bennett, F. C. & Harvey, K. F. Fat cadherin modulates organ size in _Drosophila_ via the Salvador/Warts/Hippo signalling pathway. _Curr.

Biol._ 12 Oct 2006 (doi:10.1016/j.cub.2006.09.045) * Silva, E., Tsatskis, Y., Gardano, L., Tapon, N., & McNeill, H. The tumour-suppressor gene fat controls tissue growth upstream of

Expanded in the Hippo signalling pathway. _Curr. Biol._ 19 Sep 2006 (doi:10.1016/j.cub. 2006.09.004) * Willecke, M. et al. The Fat cadherin acts through the Hippo tumoursuppressor pathway to

regulate tissue size. _Curr. Biol._ 19 Sep 2006 (doi:10.1016/j.cub.2006.09.005) Download references Authors * Gemma Alderton View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Alderton, G. Expanding the pathway. _Nat Rev Cancer_ 6, 903 (2006).

https://doi.org/10.1038/nrc2035 Download citation * Published: 16 November 2006 * Issue Date: 01 December 2006 * DOI: https://doi.org/10.1038/nrc2035 SHARE THIS ARTICLE Anyone you share the

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