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Access through your institution Buy or subscribe miRNAs are short RNA molecules that are initially transcribed as long primary transcripts (pri-miRNA) that are processed to make mature
miRNAs. They regulate the stability or translational efficiency of their target mRNAs and can be involved in the regulation of differentiation, proliferation or apoptosis. As the
transcription factor MYC is also involved in regulating proliferation and apoptosis, and is involved in tumorigenesis, Joshua Mendell and colleagues asked if any miRNAs are MYC regulated.
They used a spotted oligonucleotide array of 235 miRNAs to analyse MYC-dependent miRNA expression in a human B-cell line expressing a tetracycline-responsive _MYC_ transgene. Six miRNAs were
upregulated in the MYC-overexpressing cells and these corresponded to transcripts from the _mir-17_ cluster. After verifying that MYC also upregulates a subset of these miRNAs in rat
fibroblasts, the authors addressed whether MYC binds to the _mir-17_ locus. Seven putative MYC-binding sites were found and MYC was shown to bind an atypical MYC consensus sequence within
intron 1 of the _mir-17_ cluster primary transcript. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this
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support REFERENCES ORIGINAL RESEARCH PAPERS * O'Donnell, K. A. et al. c-Myc-regulated microRNAs modulate E2F1 expression. _Nature_ 435, 839–843 (2005) Article CAS Google Scholar *
He, L. et al. A microRNA polycistron as a potential human oncogene. _Nature_ 435, 828–833 (2005) Article CAS Google Scholar FURTHER READING * Lu, J. et al. MicroRNA expression profiles
classify human cancers. _Nature_ 435, 843–838 (2005) Article Google Scholar Download references Authors * Nicola McCarthy View author publications You can also search for this author
inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McCarthy, N. Friend or foe?. _Nat Rev Cancer_ 5, 497 (2005).
https://doi.org/10.1038/nrc1658 Download citation * Published: 20 June 2005 * Issue Date: 01 July 2005 * DOI: https://doi.org/10.1038/nrc1658 SHARE THIS ARTICLE Anyone you share the
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