Trousseau's sign | Nature Reviews Cancer

Access through your institution Buy or subscribe The proto-ongogene _MET_ , which encodes the hepatocyte growth factor/scatter factor receptor, is known to be important for invasive growth

during tissue morphogenesis and repair, and is also mutated in a number of human cancers. Boccaccio and colleagues expressed a constitutively active form of human MET under the control of

the albumin promotor to limit its expression to mouse hepatocytes. Cancer most often arises from the transformation of somatic cells, so the authors used a self-inactivating lentiviral

vector to target these cells in adult mice. A GFP-expressing lentivirus was used as a control. MET was successfully expressed in the somatic hepatocytes and nodules of dysplastic cells were

evident after 3 months. By this time, however, many of the MET-expressing mice had already developed blood clots, evident in their tails, and by 6 to 7 months, as a result of the exhaustion

of the blood-coagulation system, many had haemorrhages in all major organs — a condition known as disseminated intravascular coagulation (DIC). Only 5 of 25 mice survived this and, of these,

only a few went on to develop overt liver neoplasia. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this

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support ORIGINAL RESEARCH PAPER * Boccaccio, C. et al. The _MET_ oncogene drives a genetic programme linking cancer to haemostasis. _Nature_ 434, 396–400 (2005) Article  CAS  Google Scholar

  Download references Authors * Nicola McCarthy View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE McCarthy, N. Trousseau's sign. _Nat Rev Cancer_ 5, 336 (2005). https://doi.org/10.1038/nrc1624 Download citation * Issue Date: 01 May 2005 * DOI:

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