Spaced stimuli stabilize mapk pathway activation and its effects on dendritic morphology

ABSTRACT Memory storage in mammalian neurons probably depends on both biochemical events and morphological alterations in dendrites. Here we report an activity-dependent stabilization of the

MAP kinase (MAPK) pathway, prominent in hippocampal dendrites. The longevity of the signal in these dendrites was increased to hours when multiple spaced stimuli were used. Likewise, spaced

stimuli and MAPK activation were critical for protrusion of new dendritic filopodia that also remained stable for hours. Our experiments define a new role for stimulus-specific responses of

MAPK signaling in activity-dependent neuronal plasticity. The local biochemical signaling in dendrites complements MAPK signaling in gene expression. Together, these processes may support

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our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS TRACEABLE STIMULUS-DEPENDENT RAPID MOLECULAR CHANGES IN DENDRITIC SPINES IN THE BRAIN Article Open access 17

September 2020 COMPARTMENTALIZED DENDRITIC PLASTICITY IN THE MOUSE RETROSPLENIAL CORTEX LINKS CONTEXTUAL MEMORIES FORMED CLOSE IN TIME Article Open access 17 February 2025 DENDRITIC

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Scholar  Download references ACKNOWLEDGEMENTS We thank H. Cline and H. Reuter for reading the manuscript, and members of the Tsien lab for comments and discussion. We also thank Y.-Q. Cao

for her help in the western blot experiments. This study was supported by the NIH. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Molecular and Cellular Physiology, Stanford

University School of Medicine, Stanford, 94305, California, USA Gang-Yi Wu & Richard W. Tsien * Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine,

Stanford, 94305, California, USA Karl Deisseroth Authors * Gang-Yi Wu View author publications You can also search for this author inPubMed Google Scholar * Karl Deisseroth View author

publications You can also search for this author inPubMed Google Scholar * Richard W. Tsien View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING

AUTHOR Correspondence to Richard W. Tsien. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wu, GY., Deisseroth, K. & Tsien, R. Spaced stimuli

stabilize MAPK pathway activation and its effects on dendritic morphology. _Nat Neurosci_ 4, 151–158 (2001). https://doi.org/10.1038/83976 Download citation * Received: 23 October 2000 *

Accepted: 14 December 2000 * Issue Date: February 2001 * DOI: https://doi.org/10.1038/83976 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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