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Recent studies on osteoclast apoptosis and TGF-β gene regulation provide new insights into the mechanisms by which estrogens and their analogues inhibit bone resorption (pages 1132–1136).
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support REFERENCES * Caputo, C.B., Meadows, D. & Raisz, L.G. Failure of estrogens and androgens to inhibit bone resorption in tissue culture. _Endocrinology_ 98, 1065–1068 (1976).
Article CAS Google Scholar * Horowitz, M.C. Cytokines and estrogen in bone: Anti-osteoporotic effects. _Science_ 260, 626–627 (1993). Article CAS Google Scholar * Miyaura, C. _et al_.
Endogenous bone resorbing factors and estrogen deficiency: Cooperative effects of IL-1 and IL-6. _J. Bone Miner. Res._ 10, 1365–1373 (1995). Article CAS Google Scholar * Kawaguchi, H. _et
al_. Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae. _J. Clin. Invest._ 96,
539–548 (1995). Article CAS Google Scholar * Kimble, R.B. _et al_. Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early
postovariectomy period. _Endocrinology_ 136, 3054–3061 (1995). Article CAS Google Scholar * Jilka, R.L. _et al_. Increased osteoclast development after estrogen loss: Mediation by
interleukin-6. _Science_ 257, 88–92 (1992). Article CAS Google Scholar * Vargas, S. _et al_. Lack of evidence for an increase in interleukin-6 expression in adult murine bone, bone marrow
and marrow stromal cell cultures after ovariectomy. _J. Bone Miner. Res._ (in the press). * Hughes, D.E. _et al_. Estrogen promotes apoptosis of murine osteoclasts-mediated by TGF-β.
_Nature Med._ 2, 1132–1136 (1996). Article CAS Google Scholar * Pfeilschifter, J., Seyedin, S.M. & Mundy, G.R. Transforming growth factor-β inhibits bone resorption in fetal rat long
bone cultures. _J. Clin. Invest._ 82, 680–685 (1988). Article CAS Google Scholar * Oursler, M.J. _et al_. Modulation of transforming growth factor β production in normal human
osteoblast-like cells by 17β-estradiol in parathyroid hormone. _Endocrinology_ 129, 3313–3320 (1991). Article CAS Google Scholar * Grainger, D.J. & Metcalfe, J.C. Tamoxifen: Teaching
an old drug new tricks. _Nature Med._ 2, 381–385 (1996). Article CAS Google Scholar * Draper, M.W. _et al_. A controlled trial of raloxifene (LY139481) HCl: Impact on bone turnover and
serum lipid profile in healthy postmenopausal women. _J. Bone Miner. Res._ 11, 835–842 (1996). Article CAS Google Scholar * Ke, H.Z. _et al_. Effects of droloxifene on prevention of
cancellous bone loss and bone turnover in the axial skeleton of aged, ovariectomized rats. _Bone_ 17, 491–496 (1995). Article CAS Google Scholar * Yang, N.N. _et al_. Identification of an
estrogen response element activated by metabolites and 17β-estradiol and raloxifene. _Science_ 273, 1222–1224 (1996). Article CAS Google Scholar * Raisz, L.G. The interaction of local
and systemic factors in the pathogenesis of osteoporosis. in _Osteoporosis_. (eds. Marcus, R., Feldman, D., Kelsey, J.) 661–670 (Academic Press, San Diego, 1996). Google Scholar Download
references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, 06030, USA Lawrence G. Raisz Authors *
Lawrence G. Raisz View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE
Raisz, L. Estrogen and bone: New pieces to the puzzle. _Nat Med_ 2, 1077–1078 (1996). https://doi.org/10.1038/nm1096-1077 Download citation * Issue Date: 01 October 1996 * DOI:
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