Enhanced expression of pai–1 in visceral fat: possible contributor to vascular disease in obeisty

ABSTRACT The presence of obesity increases the risk of thrombotic vascular diseases. The role of fat accumulation and its effect on plasminogen activator inhibitor–1 (PAI–1) levels was

investigated in humans and animals. Plasma PAI–1 levels were closely correlated with visceral fat area but not with subcutaneous fat area in human subjects. PAI–1 mRNA was detected in both

types of fat tissue in obese rats but increased only in visceral fat during the development of obesity. These data suggest that an enhanced expression of the _PAI–1_ gene in visceral fat may

increase plasma levels and may have a role in the development of vascular disease in visceral obesity. Access through your institution Buy or subscribe This is a preview of subscription

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PARTITIONING BY ADIPOSE-DERIVED ANGPTL4 IN MICE Article Open access 12 April 2021 ROLE OF PAI-1 IN HEPATIC STEATOSIS AND DYSLIPIDEMIA Article Open access 11 January 2021 ROLE OF RAGE IN

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AFFILIATIONS * Second Department of Internal Medicine, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, 565, Japan Iichiro Shimomura, Tohru Funahasm, Masahiko Takahashi, 

Kazuhisa Maeda, Kazuaki Kotani, Tadashi Nakamura, Shizuya Yamashita, Kaoru Takemura, Katsuto Tokunaga & Yuji Matsuzawa * Mitsubishi Kagaku Bioclinical Laboratories, 3-30-1 Shimura,

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Takahashi, M. _et al._ Enhanced expression of _PAI–1_ in visceral fat: Possible contributor to vascular disease in obeisty. _Nat Med_ 2, 800–803 (1996). https://doi.org/10.1038/nm0796-800

Download citation * Received: 18 January 1996 * Accepted: 15 May 1996 * Published: 01 July 1996 * Issue Date: 01 July 1996 * DOI: https://doi.org/10.1038/nm0796-800 SHARE THIS ARTICLE Anyone

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