Evidence for the involvement of endotheliai cell integrin αvβ3 in the disruption of the tumor vascuiature induced by tnf and ifn-γ

ABSTRACT Administration of tumor necrosis factor (TNF) and γ interferon (IFN-γ) to melanoma patients causes selective disruption of the tumor vascuiature but the mechanism of this disruption

is unknown. Here we report that exposure of human endotheliai cells to TNF and IFN-γ results in a reduced activation of integrin αVβ3, an adhesion receptor that plays a key role in tumor

angiogenesis, leading to a decreased αVβ3-dependent endotheliai cell adhesion and survival. Detachment and apoptosis of angiogenic endotheliai cells was demonstrated in vivo in melanoma

metastases of patients treated with TNF and IFN-γ. These results implicate integrin αVβ3 in the anti-vascular activity of TNF and IFN-γ and demonstrate a new mechanism by which cytokines

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(1994). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Centre Pluridisciplinaire d'Oncologie (CPO), School of Medicine, University of

Lausanne, Centre Hospitalier Universitaire Vaudois, c/o ISREC, 155 Chemin des Boveresses, CH-1066, Epalinges, Switzerland Curzio Rüegg, Aysim Yilmaz, Grégory Bieler & Ferdy J. Lejeune *

Swiss Institute for Experimental Cancer Research (ISREC), 155 Chemin des Boveresses, CH-1066, Epalinges, Switzerland Jeannine Bamat * Institute of Pathology, School of Medicine, University

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permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Rüegg, C., Yilmaz, A., Bieler, G. _et al._ Evidence for the involvement of endotheliai cell integrin αVβ3 in the disruption of the tumor

vascuiature induced by TNF and IFN-γ. _Nat Med_ 4, 408–414 (1998). https://doi.org/10.1038/nm0498-408 Download citation * Received: 21 October 1997 * Accepted: 18 February 1998 * Issue Date:

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