The survival kit of mycobacterium tuberculosis

Persistence of _Mycobacterium tuberculosis_ in humans depends on its ability to survive within the host macrophage. So the bacterium must resist antimicrobial mechanisms or subvert

macrophage signaling pathways to prevent its death. Recent evidence suggests that the two strategies are not mutually exclusive. Access through your institution Buy or subscribe This is a

preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per

year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated

during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Voskuil, M.I. et al. _J. Exp. Med._ 198,

705–713 (2003). Article  CAS  Google Scholar  * Walburger, A. et al. _Science_ 304, 1800–1804 (2004). Article  CAS  Google Scholar  * Rengarajan, J., Bloom, B.R. & Rubin, E.J. _Proc.

Natl. Acad. Sci. USA_ 102, 8327–8332 (2005). Article  CAS  Google Scholar  * Nathan, C. & Shiloh, M.U. _Proc. Natl. Acad. Sci. USA_ 97, 8841–8848 (2000). Article  CAS  Google Scholar  *

Schnappinger, D. et al. _J. Exp. Med._ 198, 693–704 (2003). Article  CAS  Google Scholar  * Shi, L., Jung, Y.J., Tyagi, S., Gennaro, M.L. & North, R.J. _Proc. Natl. Acad. Sci. USA_ 100,

241–246 (2003). Article  CAS  Google Scholar  * Park, H.D. et al. _Mol. Microbiol._ 48, 833–843 (2003). Article  CAS  Google Scholar  * Roberts, D.M., Liao, R.P., Wisedchaisri, G., Hol, W.G.

& Sherman, D.R. _J. Biol. Chem._ 279, 23082–23087 (2004). Article  CAS  Google Scholar  * Leyten, E.M. et al. _Microbes Infect._ 8, 2052–2060 (2006). Article  CAS  Google Scholar  *

Chua, J., Vergne, I., Master, S. & Deretic, V. _Curr. Opin. Microbiol._ 7, 71–77 (2004). Article  CAS  Google Scholar  * Pethe, K. et al. _Proc. Natl. Acad. Sci. USA_ 101, 13642–13647

(2004). Article  CAS  Google Scholar  * Nguyen, L. et al. _J. Bacteriol._ 187, 5852–5856 (2005). Article  CAS  Google Scholar  * Cowley, S. et al. _Mol. Microbiol._ 52, 1691–1702 (2004).

Article  CAS  Google Scholar  * Niebisch, A., Kabus, A., Schultz, C., Weil, B. & Bott, M. _J. Biol. Chem._ 281, 12300–12307 (2006). Article  CAS  Google Scholar  * Sassetti, C.M., Boyd,

D.H. & Rubin, E.J. _Mol. Microbiol._ 48, 77–84 (2003). Article  CAS  Google Scholar  * Sassetti, C.M. & Rubin, E.J. _Proc. Natl. Acad. Sci. USA_ 100, 12989–12994 (2003). Article  CAS

  Google Scholar  * Hensel, M. et al. _Science_ 269, 400–403 (1995). Article  CAS  Google Scholar  * Lamichhane, G. & Bishai, W. _Nat. Med._ 13, 280–282 (2007). Article  CAS  Google

Scholar  * Warner, D.F. & Mizrahi, V. _Clin. Microbiol. Rev._ 19, 558–570 (2006). Article  CAS  Google Scholar  * Nguyen, L. & Pieters, J. _Trends Cell Biol._ 15, 269–276 (2005).

Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Molecular Mycobacteriology Research Unit and Centre of Excellence for Biomedical Tuberculosis

Research, School of Pathology, University of the Witwatersrand and National Health Laboratory Service, de Korte Street, Johannesburg, 2000, South Africa Digby F Warner & Valerie Mizrahi

Authors * Digby F Warner View author publications You can also search for this author inPubMed Google Scholar * Valerie Mizrahi View author publications You can also search for this author

inPubMed Google Scholar ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE Warner, D., Mizrahi, V. The survival kit of _Mycobacterium tuberculosis_. _Nat Med_ 13, 282–284 (2007). https://doi.org/10.1038/nm0307-282 Download citation * Issue Date: March

2007 * DOI: https://doi.org/10.1038/nm0307-282 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative