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ABSTRACT FAS LIGAND (FASL) TRIGGERS APOPTOSIS DURING CYTOTOXICITY MEDIATED BY CYTOTOXIC T LYMPHOCYTES AND DURING IMMUNE DOWNREGULATION 1 . THE ABILITY OF T CELLS AND NATURAL KILLER CELLS TO
TRIGGER APOPTOSIS THROUGH THIS MECHANISM IS CONTROLLED BY THE CELL SURFACE EXPRESSION OF FASL ( ref. 2 ). BECAUSE FASL EXPRESSION IS UPREGULATED ON ACTIVATION 2, 3 , FASL WAS THOUGHT TO BE
DELIVERED DIRECTLY TO THE CELL SURFACE. HERE WE SHOW THAT NEWLY SYNTHESIZED FASL IS STORED IN SPECIALIZED SECRETORY LYSOSOMES IN BOTH CD4 + AND CD8 + T CELLS AND NATURAL KILLER CELLS, AND
THAT POLARIZED DEGRANULATION CONTROLS THE DELIVERY OF FASL TO THE CELL SURFACE. IN THIS WAY, FASL-MEDIATED APOPTOSIS IS FINELY CONTROLLED BY RECEPTOR-MEDIATED TARGET-CELL RECOGNITION. THE
CYTOPLASMIC TAIL OF FASL CONTAINS SIGNALS THAT SORT FASL TO SECRETORY LYSOSOMES IN HEMOPOIETIC CELLS. THIS PATHWAY MAY PROVIDE A GENERAL MECHANISM FOR CONTROLLING THE CELL SURFACE APPEARANCE
OF PROTEINS INVOLVED IN IMMUNE REGULATION. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access
through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink *
Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional
subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS TROGOCYTIC MOLTING OF T CELL MICROVILLI UPREGULATES T CELL RECEPTOR SURFACE EXPRESSION AND
PROMOTES CLONAL EXPANSION Article Open access 24 May 2023 DIFFERENCES IN CD80 AND CD86 TRANSENDOCYTOSIS REVEAL CD86 AS A KEY TARGET FOR CTLA-4 IMMUNE REGULATION Article Open access 23 August
2022 TIM-3 DRIVES TEMPORAL DIFFERENCES IN RESTIMULATION-INDUCED CELL DEATH SENSITIVITY IN EFFECTOR CD8+ T CELLS IN CONJUNCTION WITH CEACAM1 Article Open access 14 April 2021 REFERENCES *
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AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE G. Bossi & G.M. Griffiths Authors * G. Bossi
View author publications You can also search for this author inPubMed Google Scholar * G.M. Griffiths View author publications You can also search for this author inPubMed Google Scholar
CORRESPONDING AUTHOR Correspondence to G.M. Griffiths. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bossi, G., Griffiths, G. Degranulation plays an
essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells. _Nat Med_ 5, 90–96 (1999). https://doi.org/10.1038/4779 Download citation * Received:
27 October 1998 * Accepted: 18 November 1998 * Issue Date: January 1999 * DOI: https://doi.org/10.1038/4779 SHARE THIS ARTICLE Anyone you share the following link with will be able to read
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