Translational strategies and challenges in regenerative medicine

ABSTRACT The scientific community is currently witnessing substantial strides in understanding stem cell biology in humans; however, major disappointments in translating this knowledge into

medical therapies are flooding the field as well. Despite these setbacks, investigators are determined to better understand the caveats of regeneration, so that major pathways of repair and

regrowth can be exploited in treating aged and diseased tissues. Last year, in an effort to contribute to this burgeoning field, _Nature Medicine_, in collaboration with the Volkswagen

Foundation, organized a meeting with a panel of experts in regenerative medicine to identify the most pressing challenges, as well as the crucial strategies and stem cell concepts that can

best help advance the translational regenerative field. Here some experts who participated in the meeting provide an outlook at some of those key issues and concepts. Access through your

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BEING VIEWED BY OTHERS ENDURING QUESTIONS IN REGENERATIVE BIOLOGY AND THE SEARCH FOR ANSWERS Article Open access 09 November 2023 DEDIFFERENTIATION: INSPIRATION FOR DEVISING ENGINEERING

STRATEGIES FOR REGENERATIVE MEDICINE Article Open access 31 July 2020 AGEING AND REJUVENATION OF TISSUE STEM CELLS AND THEIR NICHES Article 20 July 2022 REFERENCES * Schofield, R. The

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references AUTHOR INFORMATION Author notes * Stefanie Dimmeler, Sheng Ding, Thomas A Rando and Alan Trounson: These authors contributed equally to this work. AUTHORS AND AFFILIATIONS *

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany Stefanie Dimmeler * Gladstone Institute of Cardiovascular Disease,

University of California, San Francisco, San Francisco, California, USA Sheng Ding * Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford,

California, USA Thomas A Rando * Glenn Center for the Biology of Aging at Stanford University, Stanford, California, USA Thomas A Rando * California Institute for Regenerative Medicine

(CIRM), San Francisco, California, USA Alan Trounson Authors * Stefanie Dimmeler View author publications You can also search for this author inPubMed Google Scholar * Sheng Ding View author

publications You can also search for this author inPubMed Google Scholar * Thomas A Rando View author publications You can also search for this author inPubMed Google Scholar * Alan

Trounson View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Stefanie Dimmeler, Sheng Ding, Thomas A Rando or Alan

Trounson. ETHICS DECLARATIONS COMPETING INTERESTS S. Dimmeler is founder of and adviser to t2Cure GmbH and adviser to miRagen Therapeutics. The other authors declare no conflict of interest.

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Dimmeler, S., Ding, S., Rando, T. _et al._ Translational strategies and challenges in regenerative

medicine. _Nat Med_ 20, 814–821 (2014). https://doi.org/10.1038/nm.3627 Download citation * Received: 05 June 2014 * Accepted: 05 June 2014 * Published: 06 August 2014 * Issue Date: August

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