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A public health intervention with small daily doses of vitamin B12 could be an effective way to tackle hyperhomocysteinemia — a common condition in India that influences fetal growth, risk
of type II diabetes and cardiovascular disease.
During trials, B12 was given to deficient subjects as 2 or 10 μg capsules. The 'plasma total homocysteine' (tHcy) concentration was measured before and after 4 and 12 months of
supplementation.
Vitamin B12 significantly reduced the tHcy concentration after an year.
The researchers had tested1 folic acid supplementation alongside, which showed no additional benefit or unfavourable effects.
The trial can be considered a public health scale 'proof of principle' study, following on from a high-dose, short-term intervention that they had reported in a small group of volunteers
earlier, the researchers said.
The authors of this work are from: Diabetes Unit, King Edward Memorial Hospital Research Centre, Pune, Maharashtra, India; University of Southampton, Southampton General Hospital, UK;
Department of Physiology, Anatomy and Genetics, University of Oxford, UK & Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway.
