Decrepit DCs | Nature Immunology


Play all audios:

Aging is associated with dysfunction of the immune system at various levels. In the _Proceedings of the National Academy of Sciences_, Strominger and colleagues demonstrate that aging also


impairs the ability of DCs to prime NK cells. DCs obtained from aged mice and stimulated with the RNA duplex poly(I:C) are ineffective at activating NK cells or priming their ability to


respond to tumors. This dysfunction seems to be DC intrinsic because NK cells from aged mice are essentially normal in their responsiveness when primed by DCs from young mice. The impaired


function of DCs from aged mice is a consequence of their lower expression of factors required for the priming of NK cells, such as the cytokines IL-15 and IL-18 or the plasma membrane


molecule CD48. These data offer mechanistic insights into the age-related enhanced susceptibility to viruses and cancer. _PNAS_ (15 September 2014) 10.1073/pnas.1414780111 Authors * Zoltan


Fehervari View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fehervari,


Z. Decrepit DCs. _Nat Immunol_ 15, 1008 (2014). https://doi.org/10.1038/ni.3021 Download citation * Published: 20 October 2014 * Issue Date: November 2014 * DOI:


https://doi.org/10.1038/ni.3021 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently


available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative