Mtdna clock runs out for dopaminergic neurons

New studies indicate that damage to the mitochondrial genome (mtDNA) accumulates with age, specifically in the dopaminergic neurons of the substantia nigra implicated in Parkinson disease.

These findings suggest that mtDNA damage is important in the decay of dopaminergic neurons in aging and in Parkinson disease, resulting in loss of mitochondrial function and, ultimately,

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* Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York, USA Giovanni Manfredi Authors * Giovanni Manfredi View author publications You

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dopaminergic neurons. _Nat Genet_ 38, 507–508 (2006). https://doi.org/10.1038/ng0506-507 Download citation * Issue Date: 01 May 2006 * DOI: https://doi.org/10.1038/ng0506-507 SHARE THIS

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