Natural variation at strubbelig receptor kinase 3 drives immune-triggered incompatibilities between arabidopsis thaliana accessions

ABSTRACT Accumulation of genetic incompatibilities within species can lead to reproductive isolation and, potentially, speciation. In this study, we show that allelic variation at _SRF3_

(_Strubbelig Receptor Family 3_), encoding a receptor-like kinase, conditions the occurrence of incompatibility between _Arabidopsis thaliana_ accessions. The geographical distribution of

_SRF3_ alleles reveals that allelic forms causing epistatic incompatibility with a Landsberg _erecta_ allele at the _RPP1_ resistance locus are present in _A. thaliana_ accessions in central

Asia. Incompatible _SRF3_ alleles condition for an enhanced early immune response to pathogens as compared to the resistance-dampening effect of compatible _SRF3_ forms in isogenic

backgrounds. Variation in disease susceptibility suggests a basis for the molecular patterns of a recent selective sweep detected at the _SRF3_ locus in central Asian populations. Access

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SIMILAR CONTENT BEING VIEWED BY OTHERS SINGLE AMINO ACID CHANGE ALTERS SPECIFICITY OF THE MULTI-ALLELIC WHEAT STEM RUST RESISTANCE LOCUS _SR9_ Article Open access 14 November 2023 GENOMICS

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SURROUNDING THE _S_-LOCUS AND ANALYSIS OF SFB ALLELES Article Open access 01 October 2020 ACCESSION CODES ACCESSIONS ARRAYEXPRESS * E-MEXP-2569 NCBI REFERENCE SEQUENCE * GU570412 * GU570413

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18, 337–338 (2002). Article  CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS We thank C. Alonso-Blanco, V. le Corre, M.H. Hoffmann, K. Schmid, O.A. Rognli and O. Loudet

for providing seed materials. We thank B. Huettel for microarray hybridizations. This work was funded by Deutsche Forschungsgemeinschaft SFB 680 grants (to M.R., J.E.P. and J.d.M.). The

authors also acknowledge the Max Planck Society and an International Max Planck Research School fellowship to A.V.G. AUTHOR INFORMATION Author notes * Ana V García & Jane E Parker

Present address: Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany. Present addresses: Institut Jean-Pierre Bourgin, UMR1318

INRA-AgroParisTech, Institut National de la Recherche Agronomique (INRA) Centre de Versailles-Grignon, Route de St-Cyr (RD10), Versailles Cedex, France (M.R.) and Unité de Recherche en

Génomique Végétale, INRA-Centre National de la Recherche Scientifique-Université Evry Val d'Essonne (CNRS-UEVE), Evry CEdex, France (A.V.G.)., AUTHORS AND AFFILIATIONS * Department of

Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, Cologne, Germany Rubén Alcázar, Ilkka Kronholm, Juliette de Meaux, Maarten Koornneef & Matthieu Reymond

Authors * Rubén Alcázar View author publications You can also search for this author inPubMed Google Scholar * Ana V García View author publications You can also search for this author

inPubMed Google Scholar * Ilkka Kronholm View author publications You can also search for this author inPubMed Google Scholar * Juliette de Meaux View author publications You can also search

for this author inPubMed Google Scholar * Maarten Koornneef View author publications You can also search for this author inPubMed Google Scholar * Jane E Parker View author publications You

can also search for this author inPubMed Google Scholar * Matthieu Reymond View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS R.A., M.K.,

J.E.P. and M.R. conceived the study. R.A. performed most of the experimental work with contributions from A.V.G. in the pathogen infection assays. I.K. and J.d.M. performed the computer

analysis and interpretation of Fay and Wu's _H__n_ statistics. M.K. provided accessions and European F2 populations. J.E.P. provided materials for immune analyses. M.R. performed all

statistical analyses. All authors analyzed the data. R.A., J.E.P and M.R. wrote the paper with contributions from all authors. CORRESPONDING AUTHOR Correspondence to Matthieu Reymond. ETHICS

DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. SUPPLEMENTARY INFORMATION SUPPLEMENTARY TEXT AND FIGURES Supplementary Figures 1–11 and Supplementary

Tables 1–6 (PDF 1990 kb) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Alcázar, R., García, A., Kronholm, I. _et al._ Natural variation at Strubbelig

Receptor Kinase 3 drives immune-triggered incompatibilities between _Arabidopsis thaliana_ accessions. _Nat Genet_ 42, 1135–1139 (2010). https://doi.org/10.1038/ng.704 Download citation *

Received: 30 March 2010 * Accepted: 07 October 2010 * Published: 31 October 2010 * Issue Date: December 2010 * DOI: https://doi.org/10.1038/ng.704 SHARE THIS ARTICLE Anyone you share the

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